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Novel peptides from the RAS-p21 and p53 proteins for the treatment of cancer

We have employed a novel computer-based molecular modeling method to design peptides from the ras-p21 and p53 proteins that block proliferation of cancer cells. The rationale of our approach is to identify peptide domains from each protein that alter conformation in response to oncogenic amino acid...

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Detalhes bibliográficos
Main Authors: Bowne, Wilbur B., Michl, Josef, Bluth, Martin H., Zenilman, Michael E., Pincus, Matthew R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2078333/
https://ncbi.nlm.nih.gov/pubmed/18007958
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