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Peptides from the amino terminal mdm-2-binding domain of p53, designed from conformational analysis, are selectively cytotoxic to transformed cells

We have synthesized three peptides from the mdm-2 binding domain of human p53, residues 12–26 (PPLSQETFSDLWKLL), residues 12–20, and 17–26. To enable transport of the peptides across the cell membrane and at the same time to maximize the active mdm-2 binding α-helical conformation for these peptides...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Kanovsky, Mecheal, Raffo, Anthony, Drew, Lisa, Rosal, Ramon, Do, Tamara, Friedman, Fred K., Rubinstein, Pablo, Visser, Jan, Robinson, Richard, Brandt-Rauf, Paul W., Michl, Josef, Fine, Robert L., Pincus, Matthew R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC60072/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11606716/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.211280698
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