Interdomain Stabilization Impairs CD4 Binding and Improves Immunogenicity of the HIV-1 Envelope Trimer

The HIV-1 envelope (Env) spike is a trimer of gp120/gp41 heterodimers that mediates viral entry. Binding to CD4 on the host cell membrane is the first essential step for infection but disrupts the native antigenic state of Env, posing a key obstacle to vaccine development. We locked the HIV-1 Env tr...

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Publicado no:Cell Host Microbe
Main Authors: Zhang, Peng, Gorman, Jason, Geng, Hui, Liu, Qingbo, Lin, Yin, Tsybovsky, Yaroslav, Go, Eden P., Dey, Barna, Andine, Tsion, Kwon, Alice, Patel, Mit, Gururani, Deepali, Uddin, Ferzan, Guzzo, Christina, Cimbro, Raffaello, Miao, Huiyi, McKee, Krisha, Chuang, Gwo-Yu, Martin, Loic, Sironi, Francesca, Malnati, Mauro S., Desaire, Heather, Berger, Edward A., Mascola, John R., Dolan, Michael A., Kwong, Peter D., Lusso, Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6007033/
https://ncbi.nlm.nih.gov/pubmed/29902444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2018.05.002
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