Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer

Binding of the gp120 envelope glycoprotein to the CD4 receptor is the first step in the HIV-1 infectious cycle. Although the CD4-binding site has been extensively characterized, the initial receptor interaction has been difficult to study because of major CD4-induced structural rearrangements. Here,...

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Gepubliceerd in:Nat Struct Mol Biol
Hoofdauteurs: Liu, Qingbo, Acharya, Priyamvada, Dolan, Michael A., Zhang, Peng, Guzzo, Christina, Lu, Jacky, Kwon, Alice, Gururani, Deepali, Miao, Huiyi, Bylund, Tatsiana, Chuang, Gwo-Yu, Druz, Aliaksandr, Zhou, Tongqing, Rice, William J, Wigge, Christoph, Carragher, Bridget, Potter, Clinton S., Kwong, Peter D., Lusso, Paolo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798227/
https://ncbi.nlm.nih.gov/pubmed/28218750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3382
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