Residual Complexity Does Impact Organic Chemistry and Drug Discovery: The Case of Rufomyazine and Rufomycin

[Image: see text] Residual complexity (RC) involves the impact of subtle but critical structural and biological features on drug lead validation, including unexplained effects related to unidentified impurities. RC commonly plagues drug discovery efforts due to the inherent imperfections of chromato...

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Bibliografische gegevens
Gepubliceerd in:J Org Chem
Hoofdauteurs: Choules, Mary P., Klein, Larry L., Lankin, David C., McAlpine, James B., Cho, Sang-Hyun, Cheng, Jinhua, Lee, Hanki, Suh, Joo-Won, Jaki, Birgit U., Franzblau, Scott G., Pauli, Guido F.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2018
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6006449/
https://ncbi.nlm.nih.gov/pubmed/29792329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.8b00988
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