Residual Complexity Does Impact Organic Chemistry and Drug Discovery: The Case of Rufomyazine and Rufomycin

[Image: see text] Residual complexity (RC) involves the impact of subtle but critical structural and biological features on drug lead validation, including unexplained effects related to unidentified impurities. RC commonly plagues drug discovery efforts due to the inherent imperfections of chromato...

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Bibliografiske detaljer
Udgivet i:J Org Chem
Main Authors: Choules, Mary P., Klein, Larry L., Lankin, David C., McAlpine, James B., Cho, Sang-Hyun, Cheng, Jinhua, Lee, Hanki, Suh, Joo-Won, Jaki, Birgit U., Franzblau, Scott G., Pauli, Guido F.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2018
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6006449/
https://ncbi.nlm.nih.gov/pubmed/29792329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.8b00988
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