Residual Complexity Does Impact Organic Chemistry and Drug Discovery: The Case of Rufomyazine and Rufomycin

[Image: see text] Residual complexity (RC) involves the impact of subtle but critical structural and biological features on drug lead validation, including unexplained effects related to unidentified impurities. RC commonly plagues drug discovery efforts due to the inherent imperfections of chromato...

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Bibliografski detalji
Izdano u:J Org Chem
Glavni autori: Choules, Mary P., Klein, Larry L., Lankin, David C., McAlpine, James B., Cho, Sang-Hyun, Cheng, Jinhua, Lee, Hanki, Suh, Joo-Won, Jaki, Birgit U., Franzblau, Scott G., Pauli, Guido F.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2018
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6006449/
https://ncbi.nlm.nih.gov/pubmed/29792329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.8b00988
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