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GPCRs and signal transducers: interaction stoichiometry

Until the late 1990s class A G protein-coupled receptors (GPCRs) were believed to function as monomers. Then indirect evidence that they might internalize or even signal as dimers has emerged, along with proof that class C GPCRs are obligatory dimers. Crystal structures of GPCRs and their much large...

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Publicado en:Trends Pharmacol Sci
Main Authors: Gurevich, Vsevolod V., Gurevich, Eugenia V.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6005764/
https://ncbi.nlm.nih.gov/pubmed/29739625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tips.2018.04.002
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