DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats

Several mechanisms of action have been proposed for DNA methyltransferase and histone deacetylase inhibitors (DNMTi and HDACi); mainly based on candidate gene approaches. However, less is known about their genome-wide transcriptional and epigenomic consequences. By mapping global transcription start...

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Udgivet i:Nat Genet
Main Authors: Brocks, David, Schmidt, Christopher R., Daskalakis, Michael, Jang, Hyo Sik, Shah, Nakul M., Li, Daofeng, Li, Jing, Zhang, Bo, Hou, Yiran, Laudato, Sara, Lipka, Daniel B., Schott, Johanna, Bierhoff, Holger, Assenov, Yassen, Helf, Monika, Ressnerova, Alzbeta, Islam, Md Saiful, Lindroth, Anders M., Haas, Simon, Essers, Marieke, Imbusch, Charles D., Brors, Benedikt, Oehme, Ina, Witt, Olaf, Lübbert, Michael, Mallm, Jan-Philipp, Rippe, Karsten, Will, Rainer, Weichenhan, Dieter, Stoecklin, Georg, Gerhäuser, Clarissa, Oakes, Christopher C., Wang, Ting, Plass, Christoph
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6005702/
https://ncbi.nlm.nih.gov/pubmed/28604729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3889
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