Reactivation of endogenous retroviral elements via treatment with DNMT- and HDAC-inhibitors

Inhibitors of DNA methyltransferases (DNMTis) or histone deacetylases (HDACis) are epigenetic drugs which are investigated since decades. Several have been approved and are applied in the treatment of hematopoietic and lymphatic malignancies, although their mode of action has not been fully understo...

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Pubblicato in:Cell Cycle
Autori principali: Daskalakis, Michael, Brocks, David, Sheng, Yi-Hua, Islam, Md Saiful, Ressnerova, Alzbeta, Assenov, Yassen, Milde, Till, Oehme, Ina, Witt, Olaf, Goyal, Ashish, Kühn, Alexander, Hartmann, Mark, Weichenhan, Dieter, Jung, Manfred, Plass, Christoph
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6056222/
https://ncbi.nlm.nih.gov/pubmed/29633898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2018.1442623
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