DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats

Several mechanisms of action have been proposed for DNA methyltransferase and histone deacetylase inhibitors (DNMTi and HDACi); mainly based on candidate gene approaches. However, less is known about their genome-wide transcriptional and epigenomic consequences. By mapping global transcription start...

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Pubblicato in:Nat Genet
Autori principali: Brocks, David, Schmidt, Christopher R., Daskalakis, Michael, Jang, Hyo Sik, Shah, Nakul M., Li, Daofeng, Li, Jing, Zhang, Bo, Hou, Yiran, Laudato, Sara, Lipka, Daniel B., Schott, Johanna, Bierhoff, Holger, Assenov, Yassen, Helf, Monika, Ressnerova, Alzbeta, Islam, Md Saiful, Lindroth, Anders M., Haas, Simon, Essers, Marieke, Imbusch, Charles D., Brors, Benedikt, Oehme, Ina, Witt, Olaf, Lübbert, Michael, Mallm, Jan-Philipp, Rippe, Karsten, Will, Rainer, Weichenhan, Dieter, Stoecklin, Georg, Gerhäuser, Clarissa, Oakes, Christopher C., Wang, Ting, Plass, Christoph
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6005702/
https://ncbi.nlm.nih.gov/pubmed/28604729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3889
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