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Nuclear PTEN deficiency causes microcephaly with decreased neuronal soma size and increased seizure susceptibility

Defects in phosphatase and tensin homolog (PTEN) are associated with neurological disorders and tumors. PTEN functions at two primary intracellular locations: the plasma membrane and the nucleus. At the membrane, PTEN functions as a phosphatidylinositol (3,4,5)-trisphosphate phosphatase and suppress...

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Podrobná bibliografie
Vydáno v:J Biol Chem
Hlavní autoři: Igarashi, Atsushi, Itoh, Kie, Yamada, Tatsuya, Adachi, Yoshihiro, Kato, Takashi, Murata, Daisuke, Sesaki, Hiromi, Iijima, Miho
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6005449/
https://ncbi.nlm.nih.gov/pubmed/29735527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002356
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