Deletion of ferroportin in murine myeloid cells increases iron accumulation and stimulates osteoclastogenesis in vitro and in vivo

Osteoporosis, osteopenia, and pathological bone fractures are frequent complications of iron-overload conditions such as hereditary hemochromatosis, thalassemia, and sickle cell disease. Moreover, animal models of iron overload have revealed increased bone resorption and decreased bone formation. Al...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Wang, Lei, Fang, Bin, Fujiwara, Toshifumi, Krager, Kimberly, Gorantla, Akshita, Li, Chaoyuan, Feng, Jian Q., Jennings, Michael L., Zhou, Jian, Aykin-Burns, Nukhet, Zhao, Haibo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6005439/
https://ncbi.nlm.nih.gov/pubmed/29724825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000834
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