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Inhibition of the PI3K/Akt signaling pathway reverses sorafenib-derived chemo-resistance in hepatocellular carcinoma

Long-term sorafenib treatment triggers resistance to chemotherapy in patients with hepatocellular carcinoma (HCC). In order to investigate the mechanisms of sorafenib resistance in HCC, the aim of the present study was to develop a resistant human liver cell line via long-term exposure to sorafenib....

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Bibliografski detalji
Izdano u:Oncol Lett
Glavni autori: Zhang, Hao, Wang, Qingqing, Liu, Jun, Cao, Haoqiang
Format: Artigo
Jezik:Inglês
Izdano: D.A. Spandidos 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004698/
https://ncbi.nlm.nih.gov/pubmed/29928334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2018.8536
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