PI-103 and Sorafenib Inhibit Hepatocellular Carcinoma Cell Proliferation by Blocking Ras/Raf/MAPK and PI3K/AKT/mTOR Pathways

BACKGROUND: Aberrant Ras/Raf/MAPK and PI3K/AKT/mTOR signaling pathways are found in hepatocellular carcinoma (HCC). This study reports how sorafenib (a multi-kinase inhibitor) and PI-103 (a dual PI3K/mTOR inhibitor) alone and in combination inhibit the proliferation of the HCC cell line, Huh7. MATER...

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Hauptverfasser: GEDALY, ROBERTO, ANGULO, PAUL, HUNDLEY, JONATHAN, DAILY, MICHAEL F., CHEN, CHANGGUO, KOCH, ALVARO, EVERS, B. MARK
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141822/
https://ncbi.nlm.nih.gov/pubmed/21187475
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