Heme redox potentials hold the key to reactivity differences between nitric oxide reductase and heme-copper oxidase

Despite high structural homology between NO reductases (NORs) and heme-copper oxidases (HCOs), factors governing their reaction specificity remain to be understood. Using a myoglobin-based model of NOR (Fe(B)Mb) and tuning its heme redox potentials (E°′) to cover the native NOR range, through manipu...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Bhagi-Damodaran, Ambika, Reed, Julian H., Zhu, Qianhong, Shi, Yelu, Hosseinzadeh, Parisa, Sandoval, Braddock A., Harnden, Kevin A., Wang, Shuyan, Sponholtz, Madeline R., Mirts, Evan N., Dwaraknath, Sudharsan, Zhang, Yong, Moënne-Loccoz, Pierre, Lu, Yi
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2018
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004492/
https://ncbi.nlm.nih.gov/pubmed/29802230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1720298115
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