NT3-chitosan enables de novo regeneration and functional recovery in monkeys after spinal cord injury

Spinal cord injury (SCI) often leads to permanent loss of motor, sensory, and autonomic functions. We have previously shown that neurotrophin3 (NT3)-loaded chitosan biodegradable material allowed for prolonged slow release of NT3 for 14 weeks under physiological conditions. Here we report that NT3-l...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Rao, Jia-Sheng, Zhao, Can, Zhang, Aifeng, Duan, Hongmei, Hao, Peng, Wei, Rui-Han, Shang, Junkui, Zhao, Wen, Liu, Zuxiang, Yu, Juehua, Fan, Kevin S., Tian, Zhaolong, He, Qihua, Song, Wei, Yang, Zhaoyang, Sun, Yi Eve, Li, Xiaoguang
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2018
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004491/
https://ncbi.nlm.nih.gov/pubmed/29844162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1804735115
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