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Development of apical hypertrophic cardiomyopathy with age in a transgenic mouse model carrying the cardiac actin E99K
In both humans and mice, the Glu-99-Lys (E99K) mutation in the cardiac actin gene (ACTC) results in little understood apical hypertrophic cardiomyopathy (AHCM). To determine how cross-bridge kinetics change with AHCM development, we applied sinusoidal length perturbations to skinned papillary muscle...
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| Publicado en: | J Muscle Res Cell Motil |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6003854/ https://ncbi.nlm.nih.gov/pubmed/29582353 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10974-018-9492-1 |
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