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The novel μ‐opioid receptor agonist PZM21 depresses respiration and induces tolerance to antinociception
BACKGROUND AND PURPOSE: PZM21 is a novel μ‐opioid receptor ligand that has been reported to induce minimal arrestin recruitment and be devoid of the respiratory depressant effects characteristic of classical μ receptor ligands such as morphine. We have re‐examined the signalling profile of PZM21 and...
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| 出版年: | Br J Pharmacol |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
John Wiley and Sons Inc.
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6003631/ https://ncbi.nlm.nih.gov/pubmed/29582414 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14224 |
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