The novel μ‐opioid receptor agonist PZM21 depresses respiration and induces tolerance to antinociception

BACKGROUND AND PURPOSE: PZM21 is a novel μ‐opioid receptor ligand that has been reported to induce minimal arrestin recruitment and be devoid of the respiratory depressant effects characteristic of classical μ receptor ligands such as morphine. We have re‐examined the signalling profile of PZM21 and...

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Dades bibliogràfiques
Publicat a:Br J Pharmacol
Autors principals: Hill, Rob, Disney, Alex, Conibear, Alex, Sutcliffe, Katy, Dewey, William, Husbands, Stephen, Bailey, Chris, Kelly, Eamonn, Henderson, Graeme
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003631/
https://ncbi.nlm.nih.gov/pubmed/29582414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14224
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