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miR-146a suppresses 5-lipoxygenase activating protein (FLAP) expression and Leukotriene B4 production in lung cancer cells

Arachidonic acid (AA) can be converted into prostaglandins (PGs) or leukotrienes (LTs) by the enzymatic actions of cyclooxygenases (COX-1 and COX-2) or 5-lipoxygenase (5-LO), respectively. PGs and LTs are lipid signaling molecules that have been implicated in various diseases, including multiple can...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Iacona, Joseph R., Monteleone, Nicholas J., Lutz, Carol S.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003571/
https://ncbi.nlm.nih.gov/pubmed/29928483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25482
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