miR-21-mediated regulation of 15-hydroxyprostaglandin dehydrogenase in colon cancer

Elevated prostaglandin E(2) (PGE(2)) levels are observed in colorectal cancer (CRC) patients, and this increase is associated with poor prognosis. Increased synthesis of PGE(2) in CRC has been shown to occur through COX-2-dependent mechanisms; however, loss of the PGE(2)-catabolizing enzyme, 15-hydr...

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Udgivet i:Sci Rep
Main Authors: Monteleone, Nicholas J., Moore, Ashleigh E., Iacona, Joseph R., Lutz, Carol S., Dixon, Dan A.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6443653/
https://ncbi.nlm.nih.gov/pubmed/30931980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41862-2
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