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STXBP4 regulates APC/C-mediated p63 turnover and drives squamous cell carcinogenesis
Levels of the N-terminally truncated isoform of p63 (ΔN p63), well documented to play a pivotal role in basal epidermal gene expression and epithelial maintenance, need to be strictly regulated. We demonstrate here that the anaphase-promoting complex/cyclosome (APC/C) complex plays an essential role...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6003458/ https://ncbi.nlm.nih.gov/pubmed/29735662 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1718546115 |
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