STXBP4 regulates APC/C-mediated p63 turnover and drives squamous cell carcinogenesis

Levels of the N-terminally truncated isoform of p63 (ΔN p63), well documented to play a pivotal role in basal epidermal gene expression and epithelial maintenance, need to be strictly regulated. We demonstrate here that the anaphase-promoting complex/cyclosome (APC/C) complex plays an essential role...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Rokudai, Susumu, Li, Yingchun, Otaka, Yukihiro, Fujieda, Michiru, Owens, David M., Christiano, Angela M., Nishiyama, Masahiko, Prives, Carol
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2018
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003458/
https://ncbi.nlm.nih.gov/pubmed/29735662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1718546115
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