STXBP4 regulates APC/C-mediated p63 turnover and drives squamous cell carcinogenesis

Levels of the N-terminally truncated isoform of p63 (ΔN p63), well documented to play a pivotal role in basal epidermal gene expression and epithelial maintenance, need to be strictly regulated. We demonstrate here that the anaphase-promoting complex/cyclosome (APC/C) complex plays an essential role...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Rokudai, Susumu, Li, Yingchun, Otaka, Yukihiro, Fujieda, Michiru, Owens, David M., Christiano, Angela M., Nishiyama, Masahiko, Prives, Carol
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003458/
https://ncbi.nlm.nih.gov/pubmed/29735662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1718546115
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados