CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch

Multisite phosphorylation of the PERIOD 2 (PER2) protein is the key step that determines the period of the mammalian circadian clock. Previous studies concluded that an unidentified kinase is required to prime PER2 for subsequent phosphorylation by casein kinase 1 (CK1), an essential clock component...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Narasimamurthy, Rajesh, Hunt, Sabrina R., Lu, Yining, Fustin, Jean-Michel, Okamura, Hitoshi, Partch, Carrie L., Forger, Daniel B., Kim, Jae Kyoung, Virshup, David M.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2018
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003379/
https://ncbi.nlm.nih.gov/pubmed/29784789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1721076115
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