CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch

Multisite phosphorylation of the PERIOD 2 (PER2) protein is the key step that determines the period of the mammalian circadian clock. Previous studies concluded that an unidentified kinase is required to prime PER2 for subsequent phosphorylation by casein kinase 1 (CK1), an essential clock component...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Narasimamurthy, Rajesh, Hunt, Sabrina R., Lu, Yining, Fustin, Jean-Michel, Okamura, Hitoshi, Partch, Carrie L., Forger, Daniel B., Kim, Jae Kyoung, Virshup, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003379/
https://ncbi.nlm.nih.gov/pubmed/29784789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1721076115
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