CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch

Multisite phosphorylation of the PERIOD 2 (PER2) protein is the key step that determines the period of the mammalian circadian clock. Previous studies concluded that an unidentified kinase is required to prime PER2 for subsequent phosphorylation by casein kinase 1 (CK1), an essential clock component...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Narasimamurthy, Rajesh, Hunt, Sabrina R., Lu, Yining, Fustin, Jean-Michel, Okamura, Hitoshi, Partch, Carrie L., Forger, Daniel B., Kim, Jae Kyoung, Virshup, David M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2018
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003379/
https://ncbi.nlm.nih.gov/pubmed/29784789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1721076115
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