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Mutation of a PER2 phosphodegron perturbs the circadian phosphoswitch
Casein kinase 1 (CK1) plays a central role in regulating the period of the circadian clock. In mammals, PER2 protein abundance is regulated by CK1-mediated phosphorylation and proteasomal degradation. On the other hand, recent studies have questioned whether the degradation of the core circadian mac...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7245125/ https://ncbi.nlm.nih.gov/pubmed/32354999 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2000266117 |
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