Two Ck1δ transcripts regulated by m6A methylation code for two antagonistic kinases in the control of the circadian clock

The N(6)-methylation of internal adenosines (m6A) in mRNA has been quantified and localized throughout the transcriptome. However, the physiological significance of m6A in most highly methylated mRNAs is unknown. It was demonstrated previously that the circadian clock, based on transcription-transla...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Fustin, Jean-Michel, Kojima, Rika, Itoh, Kakeru, Chang, Hsin-Yi, Ye, Shiqi, Zhuang, Bowen, Oji, Asami, Gibo, Shingo, Narasimamurthy, Rajesh, Virshup, David, Kurosawa, Gen, Doi, Masao, Manabe, Ichiro, Ishihama, Yasushi, Ikawa, Masahito, Okamura, Hitoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2018
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003373/
https://ncbi.nlm.nih.gov/pubmed/29784786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1721371115
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