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Activity-dependent aberrations in gene expression and alternative splicing in a mouse model of Rett syndrome

Rett syndrome (RTT) is a severe neurodevelopmental disorder that affects about 1 in 10,000 female live births. The underlying cause of RTT is mutations in the X-linked gene, methyl-CpG-binding protein 2 (MECP2); however, the molecular mechanism by which these mutations mediate the RTT neuropathology...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Osenberg, Sivan, Karten, Ariel, Sun, Jialin, Li, Jin, Charkowick, Shaun, Felice, Christy A., Kritzer, Mary, Nguyen, Minh Vu Chuong, Yu, Peng, Ballas, Nurit
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003366/
https://ncbi.nlm.nih.gov/pubmed/29769330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1722546115
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