DNA methylation and repressive H3K9 and H3K27 trimethylation in the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and PD-L1 genes in human primary breast cancer

BACKGROUND: High expression of immune checkpoints in tumor microenvironment plays significant roles in inhibiting anti-tumor immunity, which is associated with poor prognosis and cancer progression. Major epigenetic modifications in both DNA and histone could be involved in upregulation of immune ch...

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Veröffentlicht in:Clin Epigenetics
Hauptverfasser: Sasidharan Nair, Varun, El Salhat, Haytham, Taha, Rowaida Z., John, Anne, Ali, Bassam R., Elkord, Eyad
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003083/
https://ncbi.nlm.nih.gov/pubmed/29983831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-018-0512-1
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