DNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancer

BACKGROUND: Colorectal cancer (CRC) is the third most commonly diagnosed human malignancy worldwide. Upregulation of inhibitory immune checkpoints by tumor-infiltrating immune cells (TIICs) or their ligands by tumor cells leads to tumor evasion from host immunosurveillance. Changes in DNA methylatio...

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Detalhes bibliográficos
Publicado no:Clin Epigenetics
Main Authors: Sasidharan Nair, Varun, Toor, Salman M., Taha, Rowaida Z., Shaath, Hibah, Elkord, Eyad
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6080402/
https://ncbi.nlm.nih.gov/pubmed/30081950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-018-0539-3
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