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Blockade of PD-1, PD-L1, and TIM-3 Altered Distinct Immune- and Cancer-Related Signaling Pathways in the Transcriptome of Human Breast Cancer Explants

Immune checkpoint inhibitors (ICIs) are yet to have a major advantage over conventional therapies, as only a fraction of patients benefit from the currently approved ICIs and their response rates remain low. We investigated the effects of different ICIs—anti-programmed cell death protein 1 (PD-1), a...

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Foilsithe in:Genes (Basel)
Main Authors: Saleh, Reem, Toor, Salman M., Al-Ali, Dana, Sasidharan Nair, Varun, Elkord, Eyad
Formáid: Artigo
Teanga:Inglês
Foilsithe: MDPI 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7349021/
https://ncbi.nlm.nih.gov/pubmed/32616706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes11060703
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