Post-HTS case report and structural alert: Promiscuous 4-aroyl-1,5-disubstituted-3-hydroxy-2H-pyrrol-2-one actives verified by ALARM NMR

Despite its wide use, not every high-throughput screen (HTS) yields chemical matter suitable for drug development campaigns, and seldom are ‘go/no-go’ decisions in drug discovery described in detail. This case report describes the follow-up of a 4-aroyl-1,5-disubstituted-3-hydroxy-2H-pyrrol-2-one ac...

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Xehetasun bibliografikoak
Argitaratua izan da:Bioorg Med Chem Lett
Egile Nagusiak: Dahlin, Jayme L., Nissink, J. Willem M., Francis, Subhashree, Strasser, Jessica M., John, Kristen, Zhang, Zhiguo, Walters, Michael A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002837/
https://ncbi.nlm.nih.gov/pubmed/26318992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.08.020
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