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The Structure of the Necrosome RIPK1-RIPK3 core, a human hetero-amyloid signaling complex
The RIPK1-RIPK3 necrosome is an amyloid signaling complex that initiates TNF-induced necroptosis, serving in human immune defense, cancer and neurodegenerative diseases. RIPK1 and RIPK3 associate through their RIP homotypic interaction motifs with consensus sequences IQIG (RIPK1) and VQVG (RIPK3). U...
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| Publicado en: | Cell |
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| Autores principales: | , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6002806/ https://ncbi.nlm.nih.gov/pubmed/29681455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.03.032 |
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