Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18

The effects of transgenically encoded human and mouse IL-18 on T cell proliferation and its application in boosting chimeric antigen receptor (CAR) T cells are presented. Robust enhancement of proliferation of IL-18-secreting human T cells occurred in a xenograft model, and this was dependent on TCR...

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Bibliografske podrobnosti
izdano v:Cell Rep
Main Authors: Hu, Biliang, Ren, Jiangtao, Luo, Yanping, Keith, Brian, Young, Regina M., Scholler, John, Zhao, Yangbing, June, Carl H.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002762/
https://ncbi.nlm.nih.gov/pubmed/28954221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.09.002
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