A rational mouse model to detect on-target, off-tumor CAR T cell toxicity

Off-tumor targeting of human antigens is difficult to predict in preclinical animal studies and can lead to serious adverse effects in patients. To address this, we developed a mouse model with stable and tunable human Her2 (hHer2) expression on normal hepatic tissue and compared toxicity between af...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:JCI Insight
Egile Nagusiak: Castellarin, Mauro, Sands, Caroline, Da, Tong, Scholler, John, Graham, Kathleen, Buza, Elizabeth, Fraietta, Joseph A., Zhao, Yangbing, June, Carl H.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2020
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7453898/
https://ncbi.nlm.nih.gov/pubmed/32544101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.136012
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak