A rational mouse model to detect on-target, off-tumor CAR T cell toxicity

Off-tumor targeting of human antigens is difficult to predict in preclinical animal studies and can lead to serious adverse effects in patients. To address this, we developed a mouse model with stable and tunable human Her2 (hHer2) expression on normal hepatic tissue and compared toxicity between af...

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Publicado en:JCI Insight
Autores principales: Castellarin, Mauro, Sands, Caroline, Da, Tong, Scholler, John, Graham, Kathleen, Buza, Elizabeth, Fraietta, Joseph A., Zhao, Yangbing, June, Carl H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7453898/
https://ncbi.nlm.nih.gov/pubmed/32544101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.136012
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