Neuraminidase 1 activates insulin receptor and reverses insulin resistance in obese mice

OBJECTIVES: Neuraminidase 1 (NEU1) cleaves terminal sialic acids of glycoconjugates during lysosomal catabolism. It also modulates the structure and activity of cellular surface receptors affecting diverse pathways. Previously we demonstrated that NEU1 activates the insulin receptor (IR) and that NE...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Fougerat, Anne, Pan, Xuefang, Smutova, Victoria, Heveker, Nikolaus, Cairo, Christopher W., Issad, Tarik, Larrivée, Bruno, Medin, Jeffrey A., Pshezhetsky, Alexey V.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6001920/
https://ncbi.nlm.nih.gov/pubmed/29735266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2018.03.017
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