Neuraminidases 1 and 3 Trigger Atherosclerosis by Desialylating Low‐Density Lipoproteins and Increasing Their Uptake by Macrophages

BACKGROUND: Chronic vascular disease atherosclerosis starts with an uptake of atherogenic modified low‐density lipoproteins (LDLs) by resident macrophages, resulting in formation of arterial fatty streaks and eventually atheromatous plaques. Increased plasma sialic acid levels, increased neuraminida...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Demina, Ekaterina P., Smutova, Victoria, Pan, Xuefang, Fougerat, Anne, Guo, Tianlin, Zou, Chunxia, Chakraberty, Radhika, Snarr, Brendan D., Shiao, Tze C., Roy, Rene, Orekhov, Alexander N., Miyagi, Taeko, Laffargue, Muriel, Sheppard, Donald C., Cairo, Christopher W., Pshezhetsky, Alexey V.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7955353/
https://ncbi.nlm.nih.gov/pubmed/33554615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.120.018756
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