11Beta‐hydroxysteroid dehydrogenase‐1 deficiency or inhibition enhances hepatic myofibroblast activation in murine liver fibrosis

A hallmark of chronic liver injury is fibrosis, with accumulation of extracellular matrix orchestrated by activated hepatic stellate cells (HSCs). Glucocorticoids limit HSC activation in vitro, and tissue glucocorticoid levels are amplified by 11beta‐hydroxysteroid dehydrogenase‐1 (11βHSD1). Althoug...

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Bibliografische gegevens
Gepubliceerd in:Hepatology
Hoofdauteurs: Zou, Xiantong, Ramachandran, Prakash, Kendall, Timothy J., Pellicoro, Antonella, Dora, Elena, Aucott, Rebecca L., Manwani, Kajal, Man, Tak Yung, Chapman, Karen E., Henderson, Neil C., Forbes, Stuart J., Webster, Scott P., Iredale, John P., Walker, Brian R., Michailidou, Zoi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2018
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Original Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6001805/
https://ncbi.nlm.nih.gov/pubmed/29251794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29734
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