Ultrasensitive Capture of Human Herpes Simplex Virus Genomes Directly from Clinical Samples Reveals Extraordinarily Limited Evolution in Cell Culture

Herpes simplex viruses (HSVs) are difficult to sequence due to their large DNA genome, high GC content, and the presence of repeats. To date, most HSV genomes have been recovered from culture isolates, raising concern that these genomes may not accurately represent circulating clinical strains. We r...

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Veröffentlicht in:mSphere
Hauptverfasser: Greninger, Alexander L., Roychoudhury, Pavitra, Xie, Hong, Casto, Amanda, Cent, Anne, Pepper, Gregory, Koelle, David M., Huang, Meei-Li, Wald, Anna, Johnston, Christine, Jerome, Keith R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6001610/
https://ncbi.nlm.nih.gov/pubmed/29898986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphereDirect.00283-18
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