Ultrasensitive Capture of Human Herpes Simplex Virus Genomes Directly from Clinical Samples Reveals Extraordinarily Limited Evolution in Cell Culture

Herpes simplex viruses (HSVs) are difficult to sequence due to their large DNA genome, high GC content, and the presence of repeats. To date, most HSV genomes have been recovered from culture isolates, raising concern that these genomes may not accurately represent circulating clinical strains. We r...

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Bibliografiske detaljer
Udgivet i:mSphere
Main Authors: Greninger, Alexander L., Roychoudhury, Pavitra, Xie, Hong, Casto, Amanda, Cent, Anne, Pepper, Gregory, Koelle, David M., Huang, Meei-Li, Wald, Anna, Johnston, Christine, Jerome, Keith R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6001610/
https://ncbi.nlm.nih.gov/pubmed/29898986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphereDirect.00283-18
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