Ultrasensitive Capture of Human Herpes Simplex Virus Genomes Directly from Clinical Samples Reveals Extraordinarily Limited Evolution in Cell Culture

Herpes simplex viruses (HSVs) are difficult to sequence due to their large DNA genome, high GC content, and the presence of repeats. To date, most HSV genomes have been recovered from culture isolates, raising concern that these genomes may not accurately represent circulating clinical strains. We r...

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Bibliografske podrobnosti
izdano v:mSphere
Main Authors: Greninger, Alexander L., Roychoudhury, Pavitra, Xie, Hong, Casto, Amanda, Cent, Anne, Pepper, Gregory, Koelle, David M., Huang, Meei-Li, Wald, Anna, Johnston, Christine, Jerome, Keith R.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2018
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6001610/
https://ncbi.nlm.nih.gov/pubmed/29898986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphereDirect.00283-18
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