Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver

OBJECTIVE: Laron syndrome (LS) is a rare, autosomal recessive disorder in humans caused by loss-of-function mutations of the growth hormone receptor (GHR) gene. To establish a large animal model for LS, pigs with GHR knockout (KO) mutations were generated and characterized. METHODS: CRISPR/Cas9 tech...

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Veröffentlicht in:Mol Metab
Hauptverfasser: Hinrichs, Arne, Kessler, Barbara, Kurome, Mayuko, Blutke, Andreas, Kemter, Elisabeth, Bernau, Maren, Scholz, Armin M., Rathkolb, Birgit, Renner, Simone, Bultmann, Sebastian, Leonhardt, Heinrich, de Angelis, Martin Hrabĕ, Nagashima, Hiroshi, Hoeflich, Andreas, Blum, Werner F., Bidlingmaier, Martin, Wanke, Rüdiger, Dahlhoff, Maik, Wolf, Eckhard
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2018
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6001387/
https://ncbi.nlm.nih.gov/pubmed/29678421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2018.03.006
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