Adipocyte Xbp1s overexpression drives uridine production and reduces obesity

OBJECTIVE: The spliced transcription factor Xbp1 (Xbp1s), a transducer of the unfolded protein response (UPR), regulates lipolysis. Lipolysis is stimulated by fasting when uridine synthesis is also activated in adipocytes. METHODS: Here we have examined the regulatory role Xbp1s in stimulation of ur...

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Bibliografiske detaljer
Udgivet i:Mol Metab
Main Authors: Deng, Yingfeng, Wang, Zhao V., Gordillo, Ruth, Zhu, Yi, Ali, Aktar, Zhang, Chen, Wang, Xiaoding, Shao, Mengle, Zhang, Zhuzhen, Iyengar, Puneeth, Gupta, Rana K., Horton, Jay D., Hill, Joseph A., Scherer, Philipp E.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2018
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6001360/
https://ncbi.nlm.nih.gov/pubmed/29551634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2018.02.013
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