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New perspectives for targeting RAF kinase in human cancer

The discovery that a subset of human tumours is dependent on mutationally deregulated BRAF kinase intensified the development of RAF inhibitors to be used as potential therapeutics. The US Food and Drug Administration (FDA)-approved second-generation RAF inhibitors vemurafenib and dabrafenib have el...

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發表在:Nat Rev Cancer
Main Authors: Karoulia, Zoi, Gavathiotis, Evripidis, Poulikakos, Poulikos I.
格式: Artigo
語言:Inglês
出版: 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6000833/
https://ncbi.nlm.nih.gov/pubmed/28984291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrc.2017.79
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