Two Distinct Mechanisms for C–C Desaturation by Iron(II)- and 2-(Oxo)glutarate-Dependent Oxygenases: Importance of α-Heteroatom Assistance

Hydroxylation of aliphatic carbons by non-heme Fe(IV)-oxo (ferryl) complexes proceeds by hydrogen-atom (H•) transfer (HAT) to the ferryl and subsequent coupling between the carbon radical and Fe(III)-coordinated oxygen (termed rebound). Enzymes that use H•-abstracting ferryl complexes for other tran...

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Publicado no:J Am Chem Soc
Main Authors: Dunham, Noah P., Chang, Wei-chen, Mitchell, Andrew J., Martinie, Ryan J., Zhang, Bo, Bergman, Jonathan A., Rajakovich, Lauren J., Wang, Bo, Silakov, Alexey, Krebs, Carsten, Boal, Amie K., Bollinger, J. Martin
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5999578/
https://ncbi.nlm.nih.gov/pubmed/29708749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b01933
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