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Design of MC1R Selective γ-MSH Analogues with Canonical Amino Acids Leads to Potency and Pigmentation

Melanoma is a lethal form of skin cancer. Skin pigmentation, which is regulated by the melanocortin 1 receptor (MC1R), is an effective protection against melanoma. However, the endogenous MC1R agonists lack selectivity for the MC1R and thus can have side effects. The use of noncanonical amino acids...

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Bibliografiska uppgifter
I publikationen:J Med Chem
Huvudupphovsmän: Zhou, Yang, Haghighi, Saghar Mowlazadeh, Zoi, Ioanna, Sawyer, Jonathon R., Hruby, Victor J., Cai, Minying
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5999399/
https://ncbi.nlm.nih.gov/pubmed/29094944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b01295
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