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Replacement of Arg with Nle and modified D-Phe in the core sequence of MSHs, Ac-His-D-Phe-Arg-Trp-NH2, leads to hMC1R selectivity and pigmentation

Melanoma skin cancer is the fastest growing cancer in the US [1]. A great need exists for improved formulations and mechanisms to prevent and protect human skin from cancers and other skin damage caused by sunlight exposure. Current efforts to prevent UV damage to human skin, which in many cases lea...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Haghighi, Saghar Mowlazadeh, Zhou, Yang, Dai, Jixun, Sawyer, Jonathon R., Hruby, Victor J., Cai, Minying
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003700/
https://ncbi.nlm.nih.gov/pubmed/29679901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.04.021
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