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Replacement of Arg with Nle and modified D-Phe in the core sequence of MSHs, Ac-His-D-Phe-Arg-Trp-NH2, leads to hMC1R selectivity and pigmentation

Melanoma skin cancer is the fastest growing cancer in the US [1]. A great need exists for improved formulations and mechanisms to prevent and protect human skin from cancers and other skin damage caused by sunlight exposure. Current efforts to prevent UV damage to human skin, which in many cases lea...

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Bibliografski detalji
Izdano u:Eur J Med Chem
Glavni autori: Haghighi, Saghar Mowlazadeh, Zhou, Yang, Dai, Jixun, Sawyer, Jonathon R., Hruby, Victor J., Cai, Minying
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003700/
https://ncbi.nlm.nih.gov/pubmed/29679901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.04.021
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