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Contribution of the Conserved Amino Acids of the Melanocortin-4 Receptor in D-[Nle(4),Phe(7)]-α-Melanocyte-stimulating Hormone Binding and Signaling(□S)

Melanocortin 4 receptor (MC4R) plays an important role in the regulation of food intake and body weight. To determine the molecular basis of human MC4R (hMC4R) responsible for α-melanocortin-stimulating hormone (α-MSH) binding, in this study, we utilized both receptor domain exchange and site-direct...

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Autors principals: Chen, Min, Cai, Minying, Aprahamian, Charles J., Georgeson, Keith E., Hruby, Victor, Harmon, Carroll M., Yang, Yingkui
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704061/
https://ncbi.nlm.nih.gov/pubmed/17545153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M702285200
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